Metabolism 8.1 HL

This topic covers the way enzyme pathways form a cell's metabolism as well as specific examples of these pathways. The action of enzymes and their substrates is required as well as the way in which competitive and non-competitive inhibitors change the rate of reaction. The skill of calculating a rate of reaction from a graph of data is also part of this topic.


Key words

Learn and test your biological vocabulary using these 8.1 metabolism flash cards

Clean sweep - quick revision through the whole topic

These slides summarise the essential understanding and skills in this topic. 
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Structured question about enzymes

Answer the question below, which addresses the role of enzymes.

Explain how enzymes increase rates of reaction in metabolic pathways. (4 marks)

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Revision summary list for 8.1 Metabolism

Metabolic pathways

  • A chain or a cycle of enzyme-catalysed reactions makes a metabolic pathway.
  • Enzymes catalyse chemical reactions by lowering the activation energy.

Competitive inhibitors

  • Competitive inhibitors for example in medicine - ethanol and Fomepizole used as competitive inhibitors for antifreeze poisoning.

Non-competitive inhibitors

  • Non-competitive inhibitors. E.g. Drugs for treatment of malaria.
  • End-product inhibition can control metabolic pathways - e.g. In the pathway that converts threonine to isoleucine.

Skills

  • The use of databases to identify potential new anti-malarial drugs. In the ER role play: students will have seen this
  • In the Enzyme inhibition experiment students will calculate and plot rates of reaction from raw experimental results.
  • They will also distinguish different types of inhibition from graphs at specified substrate concentration.

Revision mind map

These diagram summaries cover the main sections of topic 8.1 Metabolism
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Review questions

This is a self marking quiz containing questions covering the topic outlined above.
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