Antibody production & vaccination 11.1 HL

This topic covers the role of antigens in challenging the immune system leading to antibody production. There are many details required including knowledge of B lymphocytes, T lymphocytes, memory cells and plasma cells. Vaccination as a method of promoting antibody production leading to immunity is an important concept in this topic as is the production of mono-clonal antibodies.


Key words

Learn and test your biological vocabulary using these 11.1 Antibodies and vaccination flashards

Clean sweep - quick revision through the whole topic

These slides summarise the essential understanding and skills in this topic. 
They contain short explanations in text and images - great revision.

Read the slides and look up any words or details you find difficult to understand.

Structured question about vaccination

Explaining the proccesses which lead to immunity following a vaccination is an important skill from this topic.

Answer the question below on a piece of paper, then check your answer against the model answer below.

Explain how exposure to antibodies leads to the production of antibodies by the immune system. [4]

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Revision summary list for 11.1 Antibody production and vaccination

Cells & pathogens

  • The surface of cells of an organism has unique molecules.
  • Pathogens can be species-specific or can cross species barriers.

Antibody production involves the following:

  • B lymphocytes are activated by T lymphocytes in mammals.
  • Activated B lymphocytes multiply to form clones of plasma cells and memory cells (giving immunity).
  • Plasma cells secrete antibodies which aid the destruction of pathogens.
  • Other white blood cells release histamine in response to allergens which causes allergic symptoms.

Vaccination and monoclonal antibodies

  • Vaccines contain antigens that trigger an immune response without causing the disease.
  • Fusion of a tumour cell with an antibody-producing plasma cell creates a hybridoma cell.
  • Monoclonal antibodies are produced by hybridoma cells
  • Monoclonal antibodies to HCG are used in pregnancy test kits.

Skills & applications

  • Smallpox was the first infectious disease of humans to have been eradicated by vaccination.
  • Human vaccines are often produced using the immune responses of other animals
  • Blood group antigens on the surface of red blood cells stimulate antibody production in a different blood group.
  • Skills to analyse epidemiological data related to vaccination programmes.

Revision mindmap

This diagram summaries the main sections of topic 11.1
Test if you can draw something like these concept maps from memory.

Review questions

This is a self marking quiz containing questions covering the topic outlined above.
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Revision fun activity

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